Active Biological Matter

Dr. Hossein Nili (IPM)
Monday, 93/09/03 (Nov. 24 2014) 15:30

In this talk, I will present my work over the past six years, all of which falls under the broad category of active biological matter. In the (considerably larger) rst part of the talk, I will present AC electrokinetic techniques as a favourable means of characterizing, separat- ing and/or manipulating biological particles through networks of microchannels comprising a lab-on-a-chip; a micro-device that integrates multiple (bio)chemical reactions onto a small chip, delivering the prospect of point-of-care diagnosis. Among the AC electrokinetic tech- niques, I focussed on dielectrophoresis (electrical force on dielectric polarization charge), which since its advent in 1951 has enjoyed ever-increasing applicability for bioparticle characteriza- tion/manipulation/separation, and will explain my task of quantitatively evaluating the sig- ni cance of multipoles in the characterizing response of non-spherical (i.e. the vast majority of) biological particles. I will show the particular necessity of including multipolar e ects as electrode structures verge towards smaller dimensions (esp. nano-electrodes). In the second part of the talk, I will present results of modelling the development of irregularly-structured bio lms (aggregates of bacteria of di erent species) that are evidently the most common cause of persistent infections. I will show the overlooked importance of bacterial inactivation within the bio lm community on the well-known resistance of bio lms to antibiotic treatment. As such, the rst part concerns (electrically) activated biological matter, and the second part con- cerns intrinsically active biological matter which is the area of endeavour my current research falls under.